Antibody Target	Cathepsin S
Alternate Name	CTSS
Host	Rabbit
Antibody Type	Polyclonal
Isotype	Rabbit IgG
Immunogen	Human Recombinant Cathepsin S, Cat # 7525
Accession #	P25774
Gene ID	1520
Appearance	Colorless liquid
Concentration	0.5 mg/ml
Formulation	100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Purification	Affinity Purified Antibody
Species Reactivity	Human, Mouse
Application	Western blot
Positive Control	Western Blot: Jurkat cell lysate, mouse muscle lysate, recombinant protein
Application & Usage	Western blot: 1-4 µg
Handling	The antibody solution should be gently mixed before use.
Storage Conditions	-20 °C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.

Description:

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

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